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UPB

Upstream Bio (UPB) stock: insider trades, news & valuation

Heavy selling
Close · Oct 9, 2026 $4.70 +3.3% on the day -76.3% over 12 months 52-week range $4.55 – $32.60

Share price and insider trades

UPB closeInsider buyInsider sale
010203040NovDecJan 2026FebMarAprMayJunJulAugSepOctSold $27,604 on 2026-09-16 · Aaron Deykin, Adam Houghton, Allison Ambrose, Everett Rand Sutherland, Michael GraySold $30,622 on 2026-06-16 · Aaron Deykin, Adam Houghton, Allison Ambrose, Everett Rand Sutherland, Michael GraySold $46,571 on 2026-03-16 · Aaron Deykin, Adam Houghton, Allison Ambrose, Everett Rand Sutherland, Michael Gray
Bought, 12 months$0
Sold, 12 months$105K
Insiders buying0
Insiders selling5

Upstream Bio insider trading at a glance (Oct 9, 2026): in the past 12 months, 0 insiders bought $0 and 5 sold $105K of UPB stock on the open market.

UPB insider buying and selling by quarter

Open-market purchases (green, above the line) and sales (red, below), by trade date.

Q1 2026: $47K sold (5 trades)Q1 2026Q2 2026: $31K sold (5 trades)Q2 2026Q3 2026: $28K sold (5 trades)Q3 2026Q4 2026
QuarterBoughtPurchasesSoldSales
Q4 2026—0—0
Q3 2026—0$28K5
Q2 2026—0$31K5
Q1 2026—0$47K5

Valuation, profit and volume

P/E (trailing)n/aSector median —
Market value— 
Profit margin—Revenue growth —
Volume vs. 50-day2.2×Last 5 sessions
Insiders' paper profit—On all tracked purchases —

Summary

Over the past 12 months, 0 Upstream Bio, Inc. insiders reported open-market purchases totaling $0, while 5 insiders reported sales totaling $105K. 0 of 15 recorded sales were made under pre-scheduled Rule 10b5-1 trading plans, which are usually less informative than discretionary sales.

Insider transactions

Open-market purchases and sales.

Filed Insider Type Shares Price Value Since Score
Sep 17SEC Everett Rand SutherlandCEO Sell 2,09568,717 held (−3%) $5.49 $12K -14.4% —
Sep 17SEC Aaron DeykinChief Medical Officer Sell 89532,302 held (−3%) $5.49 $5K -14.4% —
Sep 17SEC Michael GrayCFO, COO Sell 85327,942 held (−3%) $5.49 $5K -14.4% —
Sep 17SEC Adam HoughtonChief Business Officer Sell 70022,901 held (−3%) $5.49 $4K -14.4% —
Sep 17SEC Allison AmbroseGeneral Counsel Sell 48515,563 held (−3%) $5.49 $3K -14.4% —
Jun 17SEC Everett Rand SutherlandCEO Sell 2,09570,812 held (−3%) $6.10 $13K -23.0% —
Jun 17SEC Aaron DeykinChief Medical Officer Sell 89533,197 held (−3%) $6.10 $5K -23.0% —
Jun 17SEC Michael GrayCFO, COO Sell 85328,795 held (−3%) $6.10 $5K -23.0% —
Jun 17SEC Adam HoughtonChief Business Officer Sell 70023,601 held (−3%) $6.10 $4K -23.0% —
Jun 17SEC Allison AmbroseGeneral Counsel Sell 47716,048 held (−3%) $6.10 $3K -23.0% —
Mar 17SEC Everett Rand SutherlandCEO Sell 2,09372,907 held (−3%) $9.29 $19K -49.4% —
Mar 17SEC Aaron DeykinChief Medical Officer Sell 89432,687 held (−3%) $9.29 $8K -49.4% —
Mar 17SEC Michael GrayCFO, COO Sell 85229,648 held (−3%) $9.29 $8K -49.4% —
Mar 17SEC Adam HoughtonChief Business Officer Sell 69924,301 held (−3%) $9.29 $6K -49.4% —
Mar 17SEC Allison AmbroseGeneral Counsel Sell 47516,525 held (−3%) $9.29 $4K -49.4% —

Insiders at Upstream Bio, Inc.

InsiderBoughtSoldLast filingScore
Everett Rand SutherlandCEO — $44K Sep 17, 2026 —
Aaron DeykinChief Medical Officer — $19K Sep 17, 2026 —
Michael GrayCFO, COO — $18K Sep 17, 2026 —
Adam HoughtonChief Business Officer — $15K Sep 17, 2026 —
Allison AmbroseGeneral Counsel — $10K Sep 17, 2026 —

UPB stock: common questions

Are Upstream Bio, Inc. insiders buying UPB stock?

In the past 12 months, 0 insiders reported open-market purchases of UPB worth $0.

Are Upstream Bio, Inc. insiders selling UPB stock?

5 insiders reported sales worth $105K over the same period.

Where does this data come from?

Every transaction comes from Form 4 filings that insiders must submit to the SEC within two business days of a trade. We pull them from SEC EDGAR every night.

What is UPB's 52-week range?

Over the past year UPB has traded between $4.55 and $32.60. It last closed at $4.70 on Oct 9, 2026.