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PRAX

Praxis Precision Medicines (PRAX) stock: insider trades, news & valuation

Heavy selling
Close · Oct 9, 2026 $259.86 -1.4% on the day +374.5% over 12 months 52-week range $52.34 – $386.33

Share price and insider trades

PRAX closeInsider buyInsider sale
0100200300400NovDecJan 2026FebMarAprMayJunJulAugSepOctSold $3,611,322 on 2026-06-24 · Jill DesimoneSold $7,464,472 on 2025-11-20 · Alex Nemiroff, Lauren MastrocolaSold $33,198,220 on 2025-10-16 · Phillip Gross
Bought, 12 months$0
Sold, 12 months$44.3M
Insiders buying0
Insiders selling4

Praxis Precision Medicines insider trading at a glance (Oct 9, 2026): in the past 12 months, 0 insiders bought $0 and 4 sold $44.3M of PRAX stock on the open market.

PRAX insider buying and selling by quarter

Open-market purchases (green, above the line) and sales (red, below), by trade date.

Q4 2025: $40.7M sold (16 trades)Q4 2025Q1 2026Q2 2026: $3.6M sold (12 trades)Q2 2026Q3 2026Q4 2026
QuarterBoughtPurchasesSoldSales
Q4 2026—0—0
Q3 2026—0—0
Q2 2026—0$3.6M12
Q1 2026—0—0
Q4 2025—0$40.7M16

Valuation, profit and volume

P/E (trailing)n/aSector median —
Market value— 
Profit margin—Revenue growth —
Volume vs. 50-day1.2×Last 5 sessions
Insiders' paper profit—On all tracked purchases —

Summary

Over the past 12 months, 0 Praxis Precision Medicines, Inc. insiders reported open-market purchases totaling $0, while 4 insiders reported sales totaling $44.3M. 12 of 28 recorded sales were made under pre-scheduled Rule 10b5-1 trading plans, which are usually less informative than discretionary sales.

Insider transactions

Open-market purchases and sales.

Filed Insider Type Shares Price Value Since Score
Jun 26SEC Jill DesimoneDirector Sell Plan 2,8545,961 held (−32%) $311.91 $890K -16.7% —
Jun 26SEC Jill DesimoneDirector Sell Plan 1,7508,815 held (−17%) $310.89 $544K -16.4% —
Jun 26SEC Jill DesimoneDirector Sell Plan 1,2793,174 held (−29%) $314.90 $403K -17.5% —
Jun 26SEC Jill DesimoneDirector Sell Plan 1,24011,564 held (−10%) $308.24 $382K -15.7% —
Jun 26SEC Jill DesimoneDirector Sell Plan 1,0044,957 held (−17%) $312.83 $314K -16.9% —
Jun 26SEC Jill DesimoneDirector Sell Plan 99910,565 held (−9%) $309.38 $309K -16.0% —
Jun 26SEC Jill DesimoneDirector Sell Plan 8372,337 held (−26%) $315.71 $264K -17.7% —
Jun 26SEC Jill DesimoneDirector Sell Plan 68312,804 held (−5%) $306.77 $210K -15.3% —
Jun 26SEC Jill DesimoneDirector Sell Plan 5044,453 held (−10%) $313.66 $158K -17.2% —
Jun 26SEC Jill DesimoneDirector Sell Plan 32013,487 held (−2%) $305.31 $98K -14.9% —
Jun 26SEC Jill DesimoneDirector Sell Plan 12013,807 held (−1%) $303.13 $36K -14.3% —
Jun 26SEC Jill DesimoneDirector Sell Plan 1013,927 held (−0%) $301.44 $3K -13.8% —
Nov 21SEC Alex NemiroffGeneral Counsel Sell 13,33930,909 held (−30%) $192.53 $2.6M +35.0% —
Nov 21SEC Lauren MastrocolaPrincipal Accounting Officer Sell 11,45512,587 held (−48%) $191.96 $2.2M +35.4% —
Nov 21SEC Alex NemiroffGeneral Counsel Sell 9,10020,832 held (−30%) $194.30 $1.8M +33.7% —
Nov 21SEC Lauren MastrocolaPrincipal Accounting Officer Sell 2,14510,442 held (−17%) $192.71 $413K +34.8% —
Nov 21SEC Alex NemiroffGeneral Counsel Sell 1,71444,248 held (−4%) $190.86 $327K +36.2% —
Nov 21SEC Alex NemiroffGeneral Counsel Sell 97729,932 held (−3%) $193.23 $189K +34.5% —
Oct 17SEC Phillip Gross10% Owner Sell 250,0002,081,829 held (−11%) $104.31 $26.1M +149.1% —
Oct 17SEC Phillip Gross10% Owner Sell 27,2872,331,829 held (−1%) $101.00 $2.8M +157.3% —
Oct 17SEC Phillip Gross10% Owner Sell 19,1982,060,175 held (−1%) $140.00 $2.7M +85.6% —
Oct 17SEC Phillip Gross10% Owner Sell 12,6002,361,485 held (−1%) $90.00 $1.1M +188.7% —
Oct 17SEC Phillip Gross10% Owner Sell 1,6612,080,168 held (−0%) $130.10 $216K +99.7% —
Oct 17SEC Phillip Gross10% Owner Sell 1,3632,359,675 held (−0%) $92.03 $125K +182.4% —
Oct 17SEC Phillip Gross10% Owner Sell 4872,079,681 held (−0%) $131.64 $64K +97.4% —
Oct 17SEC Phillip Gross10% Owner Sell 5592,359,116 held (−0%) $100.11 $56K +159.6% —
Oct 17SEC Phillip Gross10% Owner Sell 3082,079,373 held (−0%) $132.19 $41K +96.6% —
Oct 17SEC Phillip Gross10% Owner Sell 4472,361,038 held (−0%) $91.04 $41K +185.4% —

Insiders at Praxis Precision Medicines, Inc.

InsiderBoughtSoldLast filingScore
Phillip Gross10% Owner — $33.2M Oct 17, 2025 —
Alex NemiroffGeneral Counsel — $4.9M Nov 21, 2025 —
Jill DesimoneDirector — $3.6M Jun 26, 2026 —
Lauren MastrocolaPrincipal Accounting Officer — $2.6M Nov 21, 2025 —

PRAX stock: common questions

Are Praxis Precision Medicines, Inc. insiders buying PRAX stock?

In the past 12 months, 0 insiders reported open-market purchases of PRAX worth $0.

Are Praxis Precision Medicines, Inc. insiders selling PRAX stock?

4 insiders reported sales worth $44.3M over the same period.

Where does this data come from?

Every transaction comes from Form 4 filings that insiders must submit to the SEC within two business days of a trade. We pull them from SEC EDGAR every night.

What is PRAX's 52-week range?

Over the past year PRAX has traded between $52.34 and $386.33. It last closed at $259.86 on Oct 9, 2026.