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ANVS

Annovis Bio (ANVS) stock: insider trades, news & valuation

Net buying
Close · Oct 9, 2026 $1.21 +3.4% on the day -45.0% over 12 months 52-week range $1.04 – $5.10

Share price and insider trades

ANVS closeInsider buyInsider sale
0246NovDecJan 2026FebMarAprMayJunJulAugSepOctEEarnings release filed 2025-11-13EEarnings release filed 2026-03-16EEarnings release filed 2026-05-15EEarnings release filed 2026-08-14Bought $31,650 on 2025-11-14 · Michael B HoffmanBought $69,900 on 2025-11-21 · Michael B HoffmanBought $142,784 on 2026-05-20 · Michael B HoffmanBought $193,800 on 2025-12-08 · Michael B HoffmanBought $319,772 on 2025-11-24 · Michael B HoffmanBought $1,498,980 on 2026-04-02 · Michael B HoffmanBought $2,200,001 on 2025-10-28 · Maria-luisa Maccecchini, Michael B Hoffman
Bought, 12 months$4.4M
Sold, 12 months$0
Insiders buying2
Insiders selling0

Annovis Bio insider trading at a glance (Oct 9, 2026): in the past 12 months, 2 insiders bought $4.4M and 0 sold $0 of ANVS stock on the open market.

ANVS insider buying and selling by quarter

Open-market purchases (green, above the line) and sales (red, below), by trade date.

Q4 2025: $2.8M bought (15 trades)$2.8MQ4 2025Q1 2026Q2 2026: $1.6M bought (4 trades)$1.6MQ2 2026Q3 2026Q4 2026
QuarterBoughtPurchasesSoldSales
Q4 2026—0—0
Q3 2026—0—0
Q2 2026$1.6M4—0
Q1 2026—0—0
Q4 2025$2.8M15—0

Valuation, profit and volume

P/E (trailing)n/aSector median —
Market value— 
Profit margin—Revenue growth —
Volume vs. 50-day0.6×Last 5 sessions
Insiders' paper profit−$2.0MOn all tracked purchases -45.1%

Summary

Over the past 12 months, 2 Annovis Bio, Inc. insiders reported open-market purchases totaling $4.4M, while 0 insiders reported sales totaling $0. Among insiders with enough purchase history to measure, Michael B Hoffman (Director) has the highest Insider Score at 2.

ANVS earnings: how the stock reacted

Each quarterly results release (SEC 8-K Item 2.02), the trend before it, insider trades in the 30 days before, and the 2-day market reaction. “E” marks releases on the chart above.

Does it matter? →
Release15 days beforeInsiders, 30 days beforeReaction (2 days)Next 30 days
Aug 14, 2026 +5.3% None -2.8%S&P -0.7% -40.2%
May 15, 2026 +15.8% None -3.8%S&P -1.3% -15.1%
Mar 16, 2026 -9.0% None +8.7%S&P +1.3% -35.0%
Nov 13, 2025 +15.7% Bought $2.2M (2) -3.7%S&P -1.7% +76.5%
Aug 12, 2025 -2.4% None -4.3%S&P +1.4% -8.1%
May 13, 2025 -1.3% None +9.0%S&P +0.8% +66.3%
Mar 21, 2025 +6.5% None +2.8%S&P +1.8% -18.4%
Nov 12, 2024 -22.5% None -3.1%S&P -0.3% -28.3%

Most companies bar insiders from trading in the weeks before results, so pre-earnings purchases are rare and often made by directors or under pre-set plans. Past reactions don't predict future ones.

Insider transactions

Open-market purchases and sales.

Filed Insider Type Shares Price Value Since Score
May 21SEC Michael B HoffmanDirector Buy 54,9333,364,883 held (+2%) $1.90 $104K -36.3% 2
May 21SEC Michael B HoffmanDirector Buy 18,8493,309,950 held (+1%) $1.80 $34K -32.8% 2
May 21SEC Michael B HoffmanDirector Buy 2,5623,291,101 held (+0%) $1.75 $4K -30.9% 2
Apr 3SEC Michael B HoffmanDirector Buy 713,8003,288,539 held (+28%) $2.10 $1.5M -42.4% 2
Dec 8SEC Michael B HoffmanDirector Buy 30,0002,559,739 held (+1%) $4.34 $130K -72.1% 2
Dec 8SEC Michael B HoffmanDirector Buy 15,0002,574,739 held (+1%) $4.24 $64K -71.5% 2
Nov 25SEC Michael B HoffmanDirector Buy 28,0962,519,739 held (+1%) $4.15 $117K -70.8% 2
Nov 25SEC Michael B HoffmanDirector Buy 28,0962,529,739 held (+1%) $4.15 $117K -70.8% 2
Nov 25SEC Michael B HoffmanDirector Buy 9,2002,491,228 held (+0%) $3.85 $35K -68.6% 2
Nov 25SEC Michael B HoffmanDirector Buy 9,2002,501,228 held (+0%) $3.85 $35K -68.6% 2
Nov 25SEC Michael B HoffmanDirector Buy 1,4892,482,028 held (+0%) $4.13 $6K -70.7% 2
Nov 25SEC Michael B HoffmanDirector Buy 1,4892,492,028 held (+0%) $4.13 $6K -70.7% 2
Nov 25SEC Michael B HoffmanDirector Buy 4152,491,643 held (+0%) $4.14 $2K -70.8% 2
Nov 25SEC Michael B HoffmanDirector Buy 4152,501,643 held (+0%) $4.14 $2K -70.8% 2
Nov 21SEC Michael B HoffmanDirector Buy 10,0002,490,539 held (+0%) $3.50 $35K -65.4% 2
Nov 21SEC Michael B HoffmanDirector Buy 10,0002,480,539 held (+0%) $3.49 $35K -65.3% 2
Nov 18SEC Michael B HoffmanDirector Buy 15,0002,470,539 held (+1%) $2.11 $32K -42.7% 2
Nov 12SEC Michael B HoffmanDirector Buy 975,6102,455,539 held (+66%) $2.05 $2.0M -41.0% 2
Nov 12SEC Maria-luisa MaccecchiniCEO, President Buy 97,5611,212,020 held (+9%) $2.05 $200K -41.0% —

Insiders at Annovis Bio, Inc.

InsiderBoughtSoldLast filingScore
Michael B HoffmanDirector $4.3M — May 21, 2026 2
Maria-luisa MaccecchiniCEO, President $200K — Nov 12, 2025 —

ANVS stock: common questions

Are Annovis Bio, Inc. insiders buying ANVS stock?

In the past 12 months, 2 insiders reported open-market purchases of ANVS worth $4.4M. The latest was Director Michael B Hoffman bought $104K of ANVS at $1.90.

Are Annovis Bio, Inc. insiders selling ANVS stock?

0 insiders reported sales worth $0 over the same period.

Where does this data come from?

Every transaction comes from Form 4 filings that insiders must submit to the SEC within two business days of a trade. We pull them from SEC EDGAR every night.

What is ANVS's 52-week range?

Over the past year ANVS has traded between $1.04 and $5.10. It last closed at $1.21 on Oct 9, 2026.